ABSTRACT
<p><b>OBJECTIVE</b>Acute Transverse myelitis (ATM) is a focal inflammatory disorder of the spinal cord, resulting in motor, sensory, and autonomic nerve dysfunction. There is often a clearly defined rostral border of sensory dysfunction. Nowadays, the pathogenesis of ATM is not clear. The present study aimed to understand possible relationship between ATM and infection with Coxsackievirus B.</p><p><b>METHODS</b>IgM antibody against Coxsackievirus B was detected in cerebrospinal fluid of 33 patients with ATM.</p><p><b>RESULTS</b>In 7 of the 33 cases with ATM, the IgM andtibody Coxsackievirus B (CVB) was positive. No infections with other pathogens were found at the onset of the disease.</p><p><b>CONCLUSION</b>The pathogenesis of ATM may involve infection with Coxsackievirus B.</p>
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Antibodies, Viral , Cerebrospinal Fluid , Allergy and Immunology , Enterovirus B, Human , Allergy and Immunology , Virulence , Physiology , Immunoglobulin M , Cerebrospinal Fluid , Allergy and Immunology , Myelitis, Transverse , Cerebrospinal Fluid , Allergy and Immunology , Pathology , Virology , Retrospective StudiesABSTRACT
<p><b>OBJECTIVE</b>To evaluate the prevalence of infection with Borna disease virus (BDV) in Chinese patients with chronic fatigue syndrome (CFS) and control subjects, and to discuss the etiological association between CFS and infection with BDV.</p><p><b>METHODS</b>The CDC (1994) diagnostic criteria for CFS were used for case definition. Sixty-one patients suffered from CFS were from 11 Provinces in China. To detect the antibody against BDV-p24 on the plasma samples from all cases and 73 healthy control subjects by Western-blotting analysis.</p><p><b>RESULTS</b>7 of the sixty-one cases and 0 of the controls were sero-positive for BDV-p24 antibody, there was a statistical significant difference between the two groups (11.48% vs 0%; P less than 0.010).</p><p><b>CONCLUSION</b>Chinese patients with CFS showed sero-positive identifying BDV infection, by comparison, anti.BDV-p24 antibody prevalence in patients was significantly higher than in controls. An etiological association may exist between CFS and BDV infection.</p>